Catenin

Catenin

[
[http://www.jbc.org/cgi/content/full/281/47/35593 Re-solving the Cadherin-Catenin-Actin Conundrum] by William I. Weis and W. James Nelson in "Journal of Biological Chemistry" (2006) Volume 281, pages 35593-35597.] ]

Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified [N. Peyrieras, D. Louvard and F. Jacob. "Characterization of antigens recognized by monoclonal and polyclonal antibodies directed against uvomorulin" in "Proceedings of the National Academy of Sciences of the United States of America" (1985) Volume 82, pages 8067-8071. PMC|2415979] became known as alpha-catenin and beta-catenin. Alpha-catenin can bind to beta-catenin and can also bind actin. Beta-catenin binds the cytoplasmic domain of some cadherins. Additional catenins such as gamma-catenin and delta-catenin have been identified. The name "catenin" was originally selected ('catena' means 'chain' in Latin) because it was suspected that catenins might link cadherins to the cytoskeleton. [M. Ozawa, H. Baribault and R. Kemler. "The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species" in "The EMBO Journal" (1989) Volume 8, pages 1711-1717. PMC|2788574]

Types

* alpha-catenin

* beta-catenin

* delta-catenin

* gamma-catenin

All but alpha contain armadillo repeats.

Catenins and cadherin function

F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by E-cadherin with beta-catenin bound to the cytoplasmic domain of E-cadherin. F9 cells were genetically engineered to lack beta-catenin, resulting in increased association of plakoglobin with E-cadherin.Y. Fukunaga, H. Liu, M. Shimizu, S. Komiya, M. Kawasuji, A. Nagafuchi. "Defining the roles of beta-catenin and plakoglobin in cell-cell adhesion: isolation of beta-catenin/plakoglobin-deficient F9 cells" in "Cell Structure and Function" (2005) Volume 30, pages 25-34. Entrez Pubmed|16357441] In F9 cells lacking both beta-catenin and plakoglobin, very little E-cadherin and alpha-catenin accumulated at the cell surface. Mice lacking beta-catenin have defective embryos. Mice engineered to specifically have vascular endothelium cells deficient in beta-catenin showed disrupted adhesion between vascular endothelial cells. [Anna Cattelino, Stefan Liebner, Radiosa Gallini, Adriana Zanetti, Giovanna Balconi, Alessandro Corsi, Paolo Bianco, Hartwig Wolburg, Robert Moore, Boussadia Oreda, Rolf Kemler and Elisabetta Dejana "The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility" in "Journal of Cell Biology" (2003) Volume 162, pages 1111-1122. Doi|10.1083/jcb.200212157] Mice lacking plakoglobin have cell adhesion defects in many tissues, although beta-catenin substitutes for plakoglobin at many cellular junctions. [Christiane Bierkamp, Heinz Schwarz, Otmar Huber and Rolf Kemler. Full text online: [http://dev.biologists.org/cgi/reprint/126/2/371 Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice] in "Development" (1999) Volume 126, pages 371-381.] Keratinocytes engineered to not express alpha-catenin have disrupted cell adhesionV. Vasioukhin, c. Bauer, L. Degenstein, B. Wise and E. Fuchs. "Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin" in "Cell" (2001) Volume 104, pages 605-617. Entrez Pubmed|11239416] and activated NF-kB. [A. Kobielak and E. Fuchs "Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin" in "Proceedings of the National Academy of Sciences of the United States of America" (2006) Volume 103, pages 2322-2327. Entrez Pubmed|16452166] A tumor cell line with defective delta-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be reverted to normal epithelial morphology and increased E-cadherin levels by expression of normal levels of functional delta-catenin.

References

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Catenin — Catenine (aus dem lat. catena für Kette) sind eine Gruppe von Proteinen, die zuerst als Verbindungsproteine zwischen Zelladhäsionsmolekülen und dem Zellcytoskelett bei bestimmten Zell Zellverbindungen, den Adherens junctions beschrieben wurden.… …   Deutsch Wikipedia

  • catenin — Cytoplasmic molecule that serves as a link between cadherins and the cytoskeleton of cells, allowing the formation of adherent junctions. There are two types: β c., which is linked to the cadherin itself and α c., which associates with actin… …   Medical dictionary

  • catenin — noun Any of a class of proteins that have a role in cell adhesion …   Wiktionary

  • Delta catenin — catenin (cadherin associated protein), delta 1 Identifiers Symbol CTNND1 Alt. symbols CTNND Entrez 1500 …   Wikipedia

  • Beta-catenin — is a subunit of the cadherin protein complex. In Drosophila , the homologous protein is called armadillo . Beta catenin has been implicated as an integral component in the Wnt signaling pathway.It can function as an oncogene.cite journal… …   Wikipedia

  • Alpha catenin — protein Name= catenin (cadherin associated protein), alpha 1, 102kDa caption= width= HGNCid=2509 Symbol=CTNNA1 AltSymbols= EntrezGene=1495 OMIM=116805 RefSeq=NM 001903 UniProt=P35221 PDB= ECnumber= Chromosome=5 Arm=q Band=31.2… …   Wikipedia

  • CTNND1 — Catenin (cadherin associated protein), delta 1 Rendering based on PDB 3L6X …   Wikipedia

  • CTNNA1 — Catenin (cadherin associated protein), alpha 1, 102kDa, also known as CTNNA1, is a human gene.cite web | title = Entrez Gene: CTNNA1 catenin (cadherin associated protein), alpha 1, 102kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • CTNNAL1 — Catenin (cadherin associated protein), alpha like 1, also known as CTNNAL1, is a human gene.cite web | title = Entrez Gene: CTNNAL1 catenin (cadherin associated protein), alpha like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • CTNNBL1 — Catenin, beta like 1, also known as CTNNBL1, is a human gene.cite web | title = Entrez Gene: CTNNBL1 catenin, beta like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=56259| accessdate = ] PBB Summary… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”