Tetrazolylglycine

Tetrazolylglycine

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IUPACName=2-amino-2-(2H-tetrazol-5-yl)acetic acid
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Section1= Chembox Identifiers
CASNo=138199-51-6
PubChem=126383
SMILES=C1(=NNN=N1)C(C(=O)O)N

Section2= Chembox Properties
Formula=C3H5N5O2
MolarMass=143.104
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Section3= Chembox Hazards
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Tetrazolylglycine (Tet-Gly, LY-285,265) is a potent and selective NMDA receptor agonist, stimulating the NMDA receptor with higher potency than either glutamate or NMDA. [Lunn WH, Schoepp DD, Calligaro DO, Vasileff RT, Heinz LJ, Salhoff CR, O'Malley PJ. DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy. "Journal of Medicinal Chemistry". 1992 Nov 27;35(24):4608-12. PMID 1361579] It is a potent convulsant and excitotoxin and is used in scientific research. [Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH. D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. "European Journal of Pharmacology". 1991 Oct 15;203(2):237-43. PMID 1686860] [Schoepp DD, Lunn WH, Salhoff CR, McDonald JW. The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin. "European Journal of Pharmacology". 1994 Jan 3;270(1):67-72. PMID 8157082]

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