Cyprodime

Cyprodime

Systematic (IUPAC) name
(–)-N-(Cyclopropylmethyl)- 4,14- dimethoxymorphinan- 6-one
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	118111-54-9 Y
ATC code	None
PubChem	CID 5748293
ChEMBL	CHEMBL322796 N
Synonyms	Cyprodime
Chemical data
Formula	C22H29NO3
Mol. mass	355.471 g/mol
N(what is this?)  (verify)

Cyprodime is an opioid antagonist from the morphinan family of drugs.

Cyprodime is a selective opioid antagonist which blocks the μ-opioid receptor,^[1] but without affecting the δ-opioid or κ-opioid receptors. This makes it useful for scientific research as it allows the μ-opioid receptor to be selectively deactivated so that the actions of the δ and κ receptors can be studied separately, in contrast to better known opioid antagonists such as naloxone which block all three opioid receptor subtypes.^[2]

References

1. ^ Schmidhammer H, Burkard WP, Eggstein-Aeppli L, Smith CF. Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N- (cyclopropylmethyl)- 4,14-dimethoxymorphinan- 6-one, a selective mu opioid receptor antagonist. Journal of Medicinal Chemistry. 1989 Feb;32(2):418-21. PMID 2536439
2. ^ Márki A, Monory K, Otvös F, Tóth G, Krassnig R, Schmidhammer H, Traynor JR, Roques BP, Maldonado R, Borsodi A. Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays. European Journal of Pharmacology. 1999 Oct 27;383(2):209-14. PMID 10585536

This analgesic-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Synthetic opioids Morphinans Opioid antagonists Ketones Ethers Phenol ethers Analgesic stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Buffalo, Kentucky WWLK Look at other dictionaries: cyprodime — noun An opioid antagonist from the morphinan family …   Wiktionary Opioid — Endogenous opioid peptides Skeletal molecular images Adrenorphin Amidorphin Casomorphin …   Wikipedia Morphinan — Preferred IUPAC name Morphinan …   Wikipedia Morphine — This article is about the drug. For other meanings, see Morphine (disambiguation). Morphia redirects here. For other uses, see Morphia (disambiguation). Not to be confused with Morphinae, Morphea, or Morpholine. Morphine …   Wikipedia Opiate — For other uses see Opiate (disambiguation), or for the class of drugs see Opioid. Harvesting the poppy pod. In medicine, the term opiate describes any of the narcotic opioid alkaloids found as natural products in the opium poppy plant …   Wikipedia Phencyclidine — Systematic (IUPAC) name …   Wikipedia Loperamide — Imodium redirects here. For the song by Nirvana, see Breed (song). Loperamide Systematic (IUPAC) name …   Wikipedia Pethidine — Systematic (IUPAC) name …   Wikipedia Opioid receptor — Opioid receptors are a group of G protein coupled receptors with opioids as ligands.[1][2][3] The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are 40% identical to somatostatin… …   Wikipedia Oxymorphone — Systematic (IUPAC) name 4,5α epoxy 3,14 dihydroxy 17 methylmorphinan 6 one Clinical data Trade names …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”