Tolrestat

Drugbox
IUPAC_name = 2-( [6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl] -methylamino)acetic acid


CAS_number = 82964-04-3
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PubChem = 53359
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chemical_formula =
C=16 | H=14 | F=3 | N=1 | O=3 | S=1
molecular_weight = 357.34 g/mol
smiles = CN(CC(=O)O)C(=S)C1=CC=CC2=C1C=CC(=C2C(F)(F)F)OC
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Tolrestat (INN) (AY-27773) is an aldose reductase inhibitorcite journal |author=Sestanj K, Bellini F, Fung S, "et al" |title=N- [5-(trifluoromethyl)-6-methoxy-1-naphthalenyl] thioxomethyl] - N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor |journal=J. Med. Chem. |volume=27 |issue=3 |pages=255–6 |year=1984 |month=March |pmid=6422042 |doi= |url=] which was approved for the control of certain diabetic complications.cite journal |author=Kador PF, Kinoshita JH, Sharpless NE |title=Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications |journal=J. Med. Chem. |volume=28 |issue=7 |pages=841–9 |year=1985 |month=July |pmid=3925146 |doi= |url=]

It was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death. It was sold under the tradename Alredase.

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